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エピジェネティクス・クロマチン

活性化物質 / 阻害物質

アクティブ・モティフ社は,DNAメチル化の変化とヒストンなどのクロマチンリモデリングタンパク質を標的とする低分子エピジェネティック調節物質(活性化物質および阻害剤)を多数扱っています。これには,DNAメチル化酵素(DNMT),ヒストンアセチル化酵素(HAT),ヒストン脱アセチル化酵素(HDAC),ヒストンメチル化酵素(HMT),ヒストン脱メチル化酵素(HDM)およびブロモドメインターゲットが含まれています。エピジェネティックな調節不全は多くの疾患に関与しているため,これらの調節物質は,そのアッセイの開発および創薬に取り組む研究者のための重要なツールになります。エピジェネティクス研究に利用可能な活性化物質および阻害剤のリストを以下に示します。

 
Name Appl. Format Cat No. 価格 (税抜)  
2'-Deoxy-5-fluorocytidine DNMT Inhibitor 250 mg 14108 ¥68,000 Buy Now
50 mg 14109 ¥21,000 Buy Now
5-Aza-2’-deoxycytidine (Decitabine) DNMT Inhibitor 50 mg 14100 ¥75,000 Buy Now
10 mg 14101 ¥28,000 Buy Now
5-Azacytidine DNMT Inhibitor 250 mg 14102 ¥19,000 Buy Now
50 mg 14103 ¥8,000 Buy Now
6-Thioguanine DNMT Inhibitor 1 g 14126 ¥28,000 Buy Now
100 mg 14127 ¥8,000 Buy Now
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥49,000 Buy Now
5 mg 14055 ¥16,000 Buy Now
Apicidin HDAC Inhibitor 5 mg 14040 ¥50,000 Buy Now
1 mg 14041 ¥18,000 Buy Now
Arecoline hydrobromide ACAT1 Inhibitor 1 g 14132 ¥18,000 Buy Now
250 mg 14133 ¥8,000 Buy Now
AS-8351 KDM5B Inhibitor 25 mg 14112 ¥50,000 Buy Now
5 mg 14113 ¥14,000 Buy Now
BIX-01294 G9a/GLP Inhibitor 25 mg 14072 ¥88,000 Buy Now
5 mg 14073 ¥33,000 Buy Now
BML-210 HDAC Inhibitor 25 mg 14048 ¥73,000 Buy Now
5 mg 14049 ¥23,000 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 ¥54,000 Buy Now
5 mg 14025 ¥18,000 Buy Now
C646 p300/CBP Inhibitor 25 mg 14052 ¥78,000 Buy Now
5 mg 14053 ¥26,000 Buy Now
Chaetocin SU(VAR)3-9 Methyltransferase Inhibitor 200 µg 14051 ¥19,000 Buy Now
CI-994 HDAC Inhibitor 25 mg 14092 ¥53,600 Buy Now
5 mg 14093 ¥15,000 Buy Now
CPTH2 Gcn5P Inhibitor 25 mg 14094 ¥53,600 Buy Now
5 mg 14095 ¥15,000 Buy Now
CTPB p300 Activator 25 mg 14064 ¥78,000 Buy Now
5 mg 14065 ¥30,000 Buy Now
CUDC-101 HDAC and Receptor Tyrosine Kinase Inhibitor 25 mg 14060 ¥104,000 Buy Now
5 mg 14061 ¥34,000 Buy Now
Daminozide KDM2/KDM7 Inhibitor 250 mg 14058 ¥32,000 Buy Now
50 mg 14059 ¥10,000 Buy Now
DMOG PHD/JMJD2A Inhibitor 50 mg 14062 ¥54,000 Buy Now
10 mg 14063 ¥17,000 Buy Now
Embelin PCAF Inhibitor 50 mg 14118 ¥46,000 Buy Now
10 mg 14119 ¥10,300 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥62,000 Buy Now
5 mg 14029 ¥19,000 Buy Now
Garcinol p300/pCAF Inhbitor 50 mg 14076 ¥64,000 Buy Now
10 mg 14077 ¥20,000 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX Inhibitor 25 mg 14068 ¥61,000 Buy Now
5 mg 14069 ¥19,000 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX Inhibitor 25 mg 14070 ¥61,000 Buy Now
5 mg 14071 ¥19,000 Buy Now
HPA (Hexyl-4-pentynoic acid) HDAC Inhibitor 50 mg 14034 ¥41,000 Buy Now
10 mg 14035 ¥10,000 Buy Now
IOX1 JMJD Family Inhibitor 25 mg 14056 ¥64,000 Buy Now
5 mg 14057 ¥20,000 Buy Now
JIB-04 JMJD Family Inhibitor 25 mg 14134 ¥40,000 Buy Now
5 mg 14135 ¥14,000 Buy Now
JQ1 (racemic) BET Bromodomain Inhibitor 25 mg 14066 ¥93,000 Buy Now
5 mg 14067 ¥31,000 Buy Now
Mithramycin A DNMT1 Inhibitor 5 mg 14128 ¥37,600 Buy Now
1 mg 14129 ¥11,000 Buy Now
ML-324 JMJD2 Inhibitor 25 mg 14078 ¥68,000 Buy Now
5 mg 14079 ¥21,000 Buy Now
Mocetinostat HDAC Inhibitor 25 mg 14136 ¥57,000 Buy Now
5 mg 14137 ¥18,000 Buy Now
MS-275 HDAC Inhibitor 25 mg 14042 ¥50,000 Buy Now
5 mg 14043 ¥19,000 Buy Now
NSC-663284 SETD8 Inhibitor 25 mg 14122 ¥68,000 Buy Now
5 mg 14123 ¥21,000 Buy Now
Panobinostat Class I and II HDAC Inhibitor 25 mg 14044 ¥50,000 Buy Now
5 mg 14045 ¥19,000 Buy Now
PBIT JARID1 Inhibitor 25 mg 14110 ¥43,000 Buy Now
5 mg 14111 ¥14,000 Buy Now
Phenylbutyrate Na HDAC Inhibitor 1 g 14033 ¥15,000 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 ¥43,000 Buy Now
5 mg 14037 ¥14,000 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 ¥43,000 Buy Now
100 mg 14023 ¥14,000 Buy Now
RG108 Non-nucleoside DNMT Inhibitor 25 mg 14104 ¥44,000 Buy Now
5 mg 14105 ¥13,000 Buy Now
Romidepsin HDAC Inhibitor 1 mg 14083 ¥46,000 Buy Now
RVX-208 BET Bromodomain Antagonist 25 mg 14090 ¥56,400 Buy Now
5 mg 14091 ¥16,000 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 ¥50,000 Buy Now
5 mg 14125 ¥23,000 Buy Now
SGC707 PRMT3 Inhibitor 25 mg 14130 ¥57,000 Buy Now
5 mg 14131 ¥18,000 Buy Now
Sinefungin Methyltransferase Inhibitor 5 mg 14088 ¥47,000 Buy Now
1 mg 14089 ¥13,200 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 ¥123,000 Buy Now
5 mg 14081 ¥35,000 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 ¥88,000 Buy Now
5 mg 14075 ¥26,000 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥46,000 Buy Now
5 mg 14087 ¥14,000 Buy Now
TC-E-5003 PRMT1 Inhibitor 50 mg 14099 ¥12,200 Buy Now
TM-2-51 HDAC8 Activator 50 mg 14096 ¥37,600 Buy Now
10 mg 14097 ¥10,300 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 Inhibitor 250 mg 14046 ¥35,000 Buy Now
50 mg 14047 ¥11,000 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥64,000 Buy Now
50 mg 14117 ¥32,000 Buy Now
Trichostatin A HDAC Inhibitor 5 mg 14038 ¥85,000 Buy Now
1 mg 14039 ¥33,000 Buy Now
Tubastatin A hydrochloride HDAC6 Inhibitor 25 mg 14084 ¥73,000 Buy Now
5 mg 14085 ¥25,000 Buy Now
UNC1999 EZH1 & EZH2 Inhibitor 25 mg 14114 ¥62,000 Buy Now
5 mg 14115 ¥25,000 Buy Now
UNC-2170 Methyl-lysine Binding Protein Inhibitor 25 mg 14120 ¥85,000 Buy Now
5 mg 14121 ¥25,000 Buy Now
Valproic Acid, sodium salt HDAC Inhibitor 5 g 14021 ¥8,000 Buy Now
Vorinostat (SAHA) HDAC Inhibitor 50 mg 14026 ¥64,000 Buy Now
10 mg 14027 ¥20,000 Buy Now
Zebularine DNMT Inhibitor 25 mg 14106 ¥47,000 Buy Now
5 mg 14107 ¥15,000 Buy Now