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HPA (Hexyl-4-pentynoic acid)

Aliases: 2-(2-propynyl)octanoic acid (racemic)
商品コード: 14034 Format: 50 mg ¥41,000 Buy Now
商品コード: 14035 Format: 10 mg ¥10,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for HPA (Hexyl-4-pentynoic acid)Chemical Properties

MW = 182.3
C11H18O2
CAS 96017-59-3
>97% (TLC); NMR (Conforms)

for HPA (Hexyl-4-pentynoic acid)Description

Valproic acid analog. Histone deacetylase (HDAC) inhibitor (IC50 = 13 M)(ref 1). More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 M), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons (ref 2). Cell permeable.

for HPA (Hexyl-4-pentynoic acid)Contents

Colorless oil. May be dissolved in DMSO (25 mg/ml); Ethanol (25 mg/ml).

for HPA (Hexyl-4-pentynoic acid)Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

for HPA (Hexyl-4-pentynoic acid)References

1. D Eikel et al. Chem. Res. Toxicol. 2006, 19:272
2. Y Leng et al. Neurosci. Lett. 2010, 476:127

 
Chemical structure of HPA.

Chemical structure of HPA.

 

Technical Data Sheet

HPA (Hexyl-4-pentynoic acid)
 

Data Thumbnails

Chemical structure of HPA.

Chemical structure of HPA.
(Click image to enlarge.)