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Trichostatin A

Aliases: TSA, (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
商品コード: 14038 Format: 5 mg ¥85,000 Buy Now
商品コード: 14039 Format: 1 mg ¥33,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for Trichostatin AChemical Properties

MW = 302.4
C17H22N2O3
CAS 58880-19-6
MP = 150-151°C
>99% (HPLC); NMR (Conforms)

for Trichostatin ADescription

Potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM)(ref 1). Induces reversion of ras-transformed cells to normal morphology (ref 2). Induces dedifferentiation of primordial germ cells into embryonic germ cells (ref 3). Cell permeable. Active in vivo.

for Trichostatin AContents

Tan powder. May be dissolved in DMSO (15 mg/ml); Ethanol (3 mg/ml).

for Trichostatin AStorage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

for Trichostatin AReferences

1. M Yoshida et al. J. Biol. Chem. 1990, 265:17174
2. M Futamura et al. Oncogene 1995, 10:1119
3. G Durcova-Hills et al. PLoS-One 2008, 3:e3531

 
Chemical structure of Trichostatin A.

Chemical structure of Trichostatin A.

 

Technical Data Sheet

Trichostatin A
 

Data Thumbnails

Chemical structure of Trichostatin A.

Chemical structure of Trichostatin A.
(Click image to enlarge.)