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IOX1

Aliases: IOX-1, 8-Hydroxy-5-quinolinecarboxylic acid; 5-Carboxy-8HQ
商品コード: 14056 Format: 25 mg ¥64,000 Buy Now
商品コード: 14057 Format: 5 mg ¥20,000 Buy Now
Application: Histone Methylation (HMT & HDM)

for IOX1Chemical Properties

MW = 189.2
C10H7NO3
CAS 5852-78-8
>98% (HPLC); NMR (Conforms)

for IOX1Description

Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6 and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively (ref 1). A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (ref 1). Cell permeable.

for IOX1Contents

Yellow powder. May be dissolved in DMSO (20 mg/ml).

for IOX1Storage Conditions

Store desiccated as supplied at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.

for IOX1References

1. ON King et al. PLoS One 2010, 5:e15535

 
Chemical structure of IOX1.

Chemical structure of IOX1.

 

Technical Data Sheet

IOX1
 

Data Thumbnails

Chemical structure of IOX1.

Chemical structure of IOX1.
(Click image to enlarge.)