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CUDC-101

Aliases: CUDC101, 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
商品コード: 14060 Format: 25 mg ¥104,000 Buy Now
商品コード: 14061 Format: 5 mg ¥34,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for CUDC-101Chemical Properties

MW = 434.5
C24H26N4O4
CAS 1012054-59-9
MP = 188-190°C
>99% (HPLC); NMR (Conforms)

for CUDC-101Description

A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2 (IC50 = 4.4 nM, 2.4 nM and 15.7 nM respectively) (ref 1). It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors (ref 1,2).

for CUDC-101Contents

White to off-white powder. May be dissolved in DMSO (25 mg/ml).

for CUDC-101Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for CUDC-101References

1. CJ Lai et al. Cancer Res. 2010, 70:3647
2. X Cai et al. J. Med. Chem. 2010, 53:2000

 
Chemical structure of CUDC-101.

Chemical structure of CUDC-101.

 

Technical Data Sheet

CUDC-101
 

Data Thumbnails

Chemical structure of CUDC-101.

Chemical structure of CUDC-101.
(Click image to enlarge.)