Active Motif,
Tools to analyze nuclear function,
Your CartYour Cart 0 items

GSK-J4 (cell permeable)

Aliases: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
商品コード: 14070 Format: 25 mg ¥61,000 Buy Now
商品コード: 14071 Format: 5 mg ¥19,000 Buy Now
Application: Histone Methylation (HMT & HDM)

for GSK-J4 (cell permeable)Chemical Properties

MW = 417.5
C24H27N5O2
CAS 1373423-53-0
>99% (TLC); NMR (Conforms)

for GSK-J4 (cell permeable)Description

Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (Catalog No. 14068)(ref1). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies (ref2).

for GSK-J4 (cell permeable)Contents

Yellow wax. May be dissolved in DMSO (40 mg/ml); Ethanol (40 mg/ml).

for GSK-J4 (cell permeable)Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

for GSK-J4 (cell permeable)References

1. L Kruidenier et al. Nature 2012, 488:404
2. SI Inoue et al. Hum. Mol. Genet. 2014 July 17, Epub.

 
Chemical structure of GSK-J4.

Chemical structure of GSK-J4.

 

Technical Data Sheet

GSK-J4 (cell permeable)
 

Data Thumbnails

Chemical structure of GSK-J4.

Chemical structure of GSK-J4.
(Click image to enlarge.)