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BIX-01294

Aliases: BIX-01294 3HCl, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
商品コード: 14072 Format: 25 mg ¥88,000 Buy Now
商品コード: 14073 Format: 5 mg ¥33,000 Buy Now
Application: Histone Methylation (HMT & HDM)

for BIX-01294Chemical Properties

MW = 600.0
C28H38N6O2 3HCl
CAS 935693-62-2
>98% (TLC); NMR (Conforms)

for BIX-01294Description

BIX-01294 is a selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 µM) as well as GLP histone methyltransferase (IC50 = 38 µM) leading to a decrease in histone H3 lysine 9 methylation (H3K9me2) in vitro (ref 1). It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming (ref 2). BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells (ref 3). It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells (ref 4).

for BIX-01294Contents

Off white crystalline solid. May be dissolved in DMSO (50 mg/ml); Water (50 mg/ml).

for BIX-01294Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

for BIX-01294References

1. S Kubicek et al. Mol. Cell 2007, 25:473
2. D Huangfu et al. Nat. Biotechnol. 2008, 26:795
3. Y Shi et al. Cell Stem Cell 2008, 2:525
4. Z Lu et al. Anticancer Drugs 2013, 24:484

 
Chemical structure of BIX-01294 3HCl.

Chemical structure of BIX-01294 3HCl.

 

Technical Data Sheet

BIX-01294
 

Data Thumbnails

Chemical structure of BIX-01294 3HCl.

Chemical structure of BIX-01294 3HCl.
(Click image to enlarge.)