Tubastatin A hydrochloride
Aliases: Tubastatin A, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride |
Catalog No: 14084 | Format: 25 mg | ¥87,000 | Buy |
Catalog No: 14085 | Format: 5 mg | ¥23,000 | Buy |
Application: Histone Acetylation (HAT & HDAC) |
Chemical Properties
MW = 371.9
C20H21N3O2• HCl
CAS 1310693-92-5
99% (HPLC); NMR (Conforms)
Description
Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold for HDAC8))(ref 1). Inhibits TNFα (IC50 = 272 nm) and IL-6 (IC50 = 712 nm) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models (ref 2). Improves survival in animal models of sepsis (ref 3). Improves cognition in Alzheimers disease transgenic mice (ref 4). Cell permeable.
Contents
White powder. May be dissolved in DMSO (50 mg/ml).
Storage Conditions
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
References
1. KV Butler et al. J. Am. Chem. Soc. 2010, 132:10842
2. S Vishwakarma et al. Int. Immunopharmacol. 2013, 16:72
3. T Zhao et al. Surg. Res. 2014, 190:647
4. L Zhang et al. J. Alzheimers Dis. 2014, 41:1193