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CPTH2

Aliases: Cyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl]hydrazone
商品コード: 14094 Format: 25 mg ¥53,600 Buy Now
商品コード: 14095 Format: 5 mg ¥15,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for CPTH2Chemical Properties

MW = 291.8
C14H14ClN3S
CAS 357649-93-5
>98% (TLC); NMR (Conforms)

for CPTH2Description

CPTH2 is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 M) (ref1). In vitro the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. In vivo it decreased acetylation of bulk histone H3 at the H3K14ac site.

for CPTH2Contents

White powder. May be dissolved in DMSO (>25 mg/ml).

for CPTH2Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for CPTH2References

1. F Chimenti et al. J. Med. Chem. 2009, 52:530

 
Chemical structure of CPTH2.

Chemical structure of CPTH2.

 

Technical Data Sheet

CPTH2
 

Data Thumbnails

Chemical structure of CPTH2.

Chemical structure of CPTH2.
(Click image to enlarge.)