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PBIT

Aliases: PBIT, 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
商品コード: 14110 Format: 25 mg ¥43,000 Buy Now
商品コード: 14111 Format: 5 mg ¥14,000 Buy Now
Application: Histone Methylation (HMT & HDM)

for PBITChemical Properties

MW = 241.3
C14H11NOS
CAS 2514-30-9
>98% (TLC); NMR (Conforms)

for PBITDescription

The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases is responsible for demethylation of trimethylated lysine 4 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 µM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B (ref 1).

for PBITContents

Off-white powder. May be dissolved in DMSO (24 mg/ml); or ethanol (5 mg/ml).

for PBITStorage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for PBITReferences

1. J Sayegh et al. J. Biol. Chem. 2013, 288:9408

 
Chemical structure of PBIT.

Chemical structure of PBIT.

 

Technical Data Sheet

PBIT
 

Data Thumbnails

Chemical structure of PBIT.

Chemical structure of PBIT.
(Click image to enlarge.)