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Salermide

Aliases: Salermide, N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methylbenzeneacetamide
商品コード: 14124 Format: 25 mg ¥50,000 Buy Now
商品コード: 14125 Format: 5 mg ¥23,000 Buy Now
Application: Sirtuins

for SalermideChemical Properties

MW = 394.5
C26H22N2O2
CAS 1105698-15-4
MP = 175-177°C
>98% (TLC); NMR (Conforms)

for SalermideDescription

SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours (ref 1). Displays protective effect in nematodes expressing muscular dystrophy protein (ref 2). Promotes neuronal apoptosis confirming the protective effect of SIRT1 (ref 3).

for SalermideContents

Yellow powder. May be dissolved in DMSO (40 mg/ml); ethanol (10 mg/ml; warm); or DMF (30 mg/ml).

for SalermideStorage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.

for SalermideReferences

1. E Lara et al. Oncogene 2009, 28:781
2. MY Pasco et al. J. Med. Chem. 2010, 53:1407
3. Y Zhao et al. Exp. Neurol. 2012, 237:489

 
Chemical structure of Salermide.

Chemical structure of Salermide.

 

Technical Data Sheet

Salermide
 

Data Thumbnails

Chemical structure of Salermide.

Chemical structure of Salermide.
(Click image to enlarge.)