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Mithramycin A

Aliases: Mithramycin A, A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin
商品コード: 14128 Format: 5 mg ¥37,600 Buy Now
商品コード: 14129 Format: 1 mg ¥11,000 Buy Now
Application: DNA Methylation

for Mithramycin AChemical Properties

MW = 1085.2
C52H76O24
CAS 18378-89-7
MP = 177°C
>98% (HPLC); NMR (Conforms)

for Mithramycin ADescription

Inhibits DNA methyltransferase (ref 1). A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression (ref 2). Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis (ref 3).

for Mithramycin AContents

Yellow powder. May be dissolved in DMSO (20 mg/ml); or ethanol (10 mg/ml).

for Mithramycin AStorage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month.

for Mithramycin AReferences

1. RK Lin et al. Anticancer Drugs 2007, 18:157
2. Z Jia et al. Cancer Res. 2010, 70:1111
3. T-J Lee et al. Mol. Cancer Ther. 2006, 5:2737

 
Chemical structure of Mithramycin A.

Chemical structure of Mithramycin A.

 

Technical Data Sheet

Mithramycin A
 

Data Thumbnails

Chemical structure of Mithramycin A.

Chemical structure of Mithramycin A.
(Click image to enlarge.)