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Recombinant SET8 D338A protein

Aliases: SETD8; KMT5A; SET07; PR-Set7
商品コード: 31322 Format: 10 µg ¥72,000 Buy Now
Expressed In: E. coli Protein Species: Human

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for Recombinant Set8 D338A proteinContents

10 µg recombinant Set8 D338A protein supplied in 20 mM Tris-HCl, pH 7.3, 100 mM KCl, 0.2 mM EDTA and 20% glycerol. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant Set8 D338A proteinApplication Notes

Recombinant Set8 D338A is suitable for use in methyltransferase assays. A recommended starting point for the methyltransferase assay is 200-500 ng of recombinant protein per reaction. The molecular weight of the protein is ~49 kDa. This is a version of the protein with a catalytic site mutant, so it is designed for use as a negative control.

for Recombinant Set8 D338A proteinProtein Details

Set8 (also known as PR-Set7 or SETD8) is a histone methyltransferase specific to lysine 20 of histone H4 (H4K20). Methylation of H4K20 is associated with transcriptional silencing. Recombinant Set8 D338A was expressed as the human protein missing amino acids 13-17 (accession number NP_065115.3) with an N-terminal His-Tag. The recombinant Set8 D338A protein contains a substitution of aspartic acid to alanine at amino acid 338. Set8 D338A is unable to methylate histone H4.

for Recombinant Set8 D338A proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.


Technical Data Sheet

Recombinant SET8 D338A protein