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Recombinant SMYD2 protein

Aliases: KMT3C; HSKM-B; ZMYND14
商品コード: 31323 Format: 10 µg ¥72,000 Buy Now
Expressed In: E. coli Protein Species: Human

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for Recombinant Smyd2 proteinContents

10 µg recombinant Smyd2 protein supplied in 20 mM Tris-HCl, pH 7.3, 100 mM KCl, 0.2 mM EDTA and 20% glycerol. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant Smyd2 proteinBackground

Smyd2 (SET and MYND domain containing protein 2) is a lysine methyltransferase that methylates both histones and non-histone proteins. Specifically, Smyd2 methylates histone H3 Lys4 (H3K4me1) and dimethylates histone H3 Lys36 (H3K36me2). Smyd2 also exhibits methyltransferase activity toward non-histone proteins such as p53 and pRb. Smyd2 monomethylates Lys370 of p53, leading to decreased DNA-binding activity and subsequent inhibition of p53-mediated transcriptional regulation. Smyd2 also monomethylates Lys860 of pRb.

for Recombinant Smyd2 proteinApplication Notes

Recombinant Smyd2 is suitable for use in methyltransferase assays. A recommended starting point for the methyltransferase assay is 50-200 ng of recombinant protein per reaction. The molecular weight of the protein is ~52 kDa.

for Recombinant Smyd2 proteinProtein Details

Smyd2 (SET and MYND domain containing protein 2) is a lysine methyltransferase for p53 and histone H3 lysine 36 (H3K36). Recombinant Smyd2 was expressed as the full-length (accession number NP_064582.2) human protein with an N-terminal His-Tag.

for Recombinant Smyd2 proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

 

Technical Data Sheet

Recombinant SMYD2 protein