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Recombinant DNMT3L protein

Aliases: DNA Methyltransferase 3 Like,
商品コード: 31414 Format: 20 µg ¥73,000 Buy Now
商品コード: 31814 Format: 1 mg ¥648,000 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant DNMT3L proteinContents

Full length recombinant DNMT3L protein is supplied in 25 mM Tris pH 8.0, 300mM NaCl, 5% Glycerol and 0.04% Triton X-100, 1mM DTT. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant DNMT3L proteinBackground

DNMT3L (DNA (Cytosine-5-)-Methyltransferase 3-Like) is a nuclear protein with similarity to the DNMT family of proteins, but does not function as a DNA methyltransferase. It serves as an essential regulator of DNMT3A and DNMT3B, recruiting them to sites for deposition of de novo DNA methylation. DNMT3L is expressed in the presumptive gametes in mammalian embryos and is required for the establishment of genomic imprinting. DNMT3L has a PHD-like domain that allows binding to chromatin through interactions with the amino terminal tail of histone H3 that is devoid of lysine 4 methylation.

for Recombinant DNMT3L proteinApplication Notes

Recombinant DNMT3L protein is suitable for use in reconstituting DNMT3 complexs, functional studies.

for Recombinant DNMT3L proteinProtein Details

Full length recombinant DNMT3L protein (accession number NP_787063.1) was expressed in Sf9 cells and contains an N-terminal 6xHis-Tag with a molecular weight of 46.6 kDa. The recombinant protein is >80% pure by SDS-PAGE.

 
DNMT3L protein Coomassie gel

Recombinant DNMT3L protein gel.
Recombinant DNMT3L protein was run on an 8% SDS-PAGE gel and stained with Coomassie blue.

for Recombinant DNMT3L proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant DNMT3L proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

 

Technical Data Sheet

Recombinant DNMT3L protein
 

Data Thumbnails

DNMT3L protein Coomassie gel

DNMT3L protein Coomassie gel.
(Click image to enlarge and see details).