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Recombinant SETMAR protein

Aliases: Mar1; HsMar1; METNASE
商品コード: 31454 Format: 20 µg ¥73,000 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant SETMAR proteinContents

Recombinant SETMAR protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant SETMAR proteinBackground

SETMAR (SET Domain and mariner transposase fusion gene) is a ubiquitously expressed nuclear fusion protein that contains an N-terminal SET domain with histone methyltransferase activity and a C-terminal mariner (MAR) transposase domain that recognizes and binds DNA. The gene exists as a fusion gene only in anthropoid primates; other organisms lack mariner transposase domain. SETMAR binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The mariner transposase domain recognizes and binds the 19-mer core of the 5’-TIR (terminal inverted repeats) of the Hsmar1 element. The SET domain specifically methylates lysines 4 and 36 of histone H3 which are epigenetic marks associated with transcriptional activation. SETMAR demonstrates in vivo end joining activity and may mediate genomic integration of foreign DNA.

for Recombinant SETMAR proteinApplication Notes

Recombinant SETMAR is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

for Recombinant SETMAR proteinProtein Details

Recombinant SETMAR (accession number NP_006506.3) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with an observed molecular weight of 79 kDa.

 
Recombinant SETMAR protein gel.

Recombinant SETMAR protein gel.
SETMAR protein was run on an 8% SDS-PAGE gel and stained with Coomassie Blue.
MW: 79 kDa
Purity: >90%

for Recombinant SETMAR proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant SETMAR proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

 

Technical Data Sheet

Recombinant SETMAR protein
 

Data Thumbnails

Recombinant SETMAR protein gel.

Recombinant SETMAR protein gel.
(Click image to enlarge and see details).