SNF5 antibody (pAb)

for SNF5 antibody (pAb)Background

SNF5 (Sucrose Non Fermenting 5, also called INI1, BAF47 and SMARCB1) is a tumor suppressor protein that is a component of the SWI/SNF chromatin-remodeling complex that regulates gene expression through alterations in chromatin structure. Alterations in chromatin structure facilitated by ATP-dependant chromatin remodeling machines are thought to enhance recognition and binding of trans-acting factors that bind DNA and regulate transcription. SNF5 signals through the p16INK4a pathway to negatively regulate cell cycle progression and mediate chromosome stability. Mutations in SNF5 are a cause of malignant rhabdoid tumors in children.

for SNF5 antibody (pAb)Immunogen

This SNF5 antibody was raised against a peptide in the C-terminus of SNF5.

for SNF5 antibody (pAb)Application Notes

This SNF5 antibody has been validated for use in Western blot (1:500 - 1:2,000 dilution).

Addition of 0.05% Tween-20 in blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot.

for SNF5 antibody (pAb)Buffer

Purified rabbit IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for SNF5 antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for SNF5 antibody (pAb)Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.