TORC2 antibody (pAb)

for TORC2 / CRTC2 antibody (pAb)Background

TORC2 (Transducer of regulated cAMP response element-binding protein 2) / CRTC2 (CREB-regulated transcription coactivator 2) is a coactivator of transcription through the CREB1 signaling pathway, independent of phosphorylation at serine 133. Involved in metabolic signaling pathways, it is responsive to glucagon signaling and regulates gluconeogenesis. It is a potent activator of mitochondrial biogenesis in muscle cells. TORC2 / CRTC2 is inactivated by phosphorylation at serine 171 (in response to both insulin signaling and the activation of AMPK), which facilitates recognition by 14-3-3 protein and subsequent translocation to the cytoplasm.

for TORC2 / CRTC2 antibody (pAb)Immunogen

This TORC2 / CRTC2 antibody was raised against a peptide at the C-terminus of human TORC2.

for TORC2 / CRTC2 antibody (pAb)Application Notes

This TORC2 / CRTC2 antibody has been tested and validated for use in Western blotting (1:500 - 1:2,000).

for TORC2 / CRTC2 antibody (pAb)Buffer

Rabbit serum containing 30% glycerol, 0.035% sodium azide.

for TORC2 / CRTC2 antibody (pAb)Positive Control

Active Motif's NIH/3T3 nuclear extract (Catalog No. 36418) can be used as a positive control for TORC2 antibody (pAb).

for TORC2 / CRTC2 antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for TORC2 / CRTC2 antibody (pAb)Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.