Sox2 antibody (pAb)

for Sox2 antibody (pAb)Background

Sox2 (SRY related HMG BOX gene 2) is a DNA binding transcription factor and a member of the SOX family of proteins. SOX proteins have an HMG box that binds DNA. Sox2 forms a complex with Oct4 and controls the expression of a number of genes involved in embryonic. Sox2 is critical for early embryogenesis and for embryonic stem cell pluripotency and thus can serve as a stem cell marker. Overexpression of Sox2 (along with Oct4, KLF4 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. Defects in Sox2 are the cause of microphthalmia syndromic type 3.

for Sox2 antibody (pAb)Immunogen

This Sox2 antibody was raised against a peptide within the C-terminal region of human Sox2.

for Sox2 antibody (pAb)Application Notes

This Sox2 antibody has been validated for use in Western blotting (1:500 - 1:1,000 dilution).

for Sox2 antibody (pAb)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for Sox2 antibody (pAb)Positive Control

Active Motif's P19 Nuclear Extract (Catalog No. 35074) can be used as a positive control for Sox2 antibody.

for Sox2 antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Sox2 antibody (pAb)Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.