Nucleophosmin antibody (pAb)

for Nucleophosmin antibody (pAb)Background

Nucleophosmin (NPM, NPM1, Nucleolar phosphoprotein B23) is a highly phosphorylated nucleolar protein involved in ribosome biogenesis, maintenance of genome stability, is directly implicated in cancer pathogenesis and serves as a histone chaperone. Nucleophosmin is closely related to Nucleoplasmin and shuttles back and forth between the nucleolus and the nucleoplasm. Chromosomal aberrations involving Nucleophosmin were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acute myelogenous leukemia. Nucleophosmin has been shown to interact with Nucleolin, AKT1, BRCA1 and BARD1. Mice deficient for Nucleophosmin have severe defects in genome stability due to unrestricted centrosome duplication. Heterozygous Nucleophosmin mutant mice show signs of myelodysplastic syndrome.

for Nucleophosmin antibody (pAb)Immunogen

This Nucleophosmin antibody was raised against a peptide within the C-terminal region of human nucleophosmin.

for Nucleophosmin antibody (pAb)Application Notes

This Nucleophosmin antibody has been validated for use in Western blotting (1:500 - 1:2,000)

for Nucleophosmin antibody (pAb)Buffer

Rabbit serum containing 30% glycerol and 0.035% sodium azide.

for Nucleophosmin antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Nucleophosmin antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of arrival.