PGC1-β antibody (pAb)

for PGC1-beta antibody (pAb)Background

PGC1-β (Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B, PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-β participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-β is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-β is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-β may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes.

for PGC1-beta antibody (pAb)Immunogen

This PGC1-β antibody antibody was raised against a peptide within the N-terminal region of human PGC1-β.

for PGC1-beta antibody (pAb)Application Notes

This PGC1-β antibody has been validated for use in Western blotting (1:500 - 1:2,000).

Addition of 0.05% Tween-20 in blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot.

for PGC1-beta antibody (pAb)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for PGC1-beta antibody (pAb)Positive Control

Active Motif's K562 nuclear extract (Catalog No. 36015) can be used as a positive control for PGC1-β antibody.

for PGC1-beta antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for PGC1-beta antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of arrival.