Osteoprotegerin (OPG) antibody (mAb)

for Osteoprotegerin (OPG) antibody (mAb)Background

Osteoprotegerin (OPG) / osteoclastogenesis inhibitory factor (OCIF) is a cytokine that can inhibit the production of osteoclasts. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60 kDa monomer or 120 kDa dimer linked by disulfide bonds. Osteoprotegerin inhibits the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitro and in vivo. Osteoprotegerin is a RANK homolog, and works by binding to RANKL ligand on osteoblast/stromal cells, thus blocking the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.

for Osteoprotegerin (OPG) antibody (mAb)Immunogen

This Osteoprotegerin (OPG) antibody was raised against a peptide corresponding to amino acid residues 20-37 of human Osteoprotegerin (OPG).

for Osteoprotegerin (OPG) antibody (mAb)Application Notes

This Osteoprotegerin (OPG) antibody has been validated for use in Western blotting (1 - 2 µg/ml dilution). For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.

for Osteoprotegerin (OPG) antibody (mAb)Buffer

PBS containing 0.02% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.

for Osteoprotegerin (OPG) antibody (mAb)Storage

Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Osteoprotegerin (OPG) antibody (mAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.