Bcl6 antibody (mAb)

for Bcl6 antibody (mAb) (Clone IG191E)Background

Bcl6 (B-cell lymphoma 6 protein, Bcl5, LAZ3, ZBTB27, ZNF51) is sequence-specific transcriptional repressor that is required for the formation of lymph node germinal centers (GC). Bcl6 is a member of the BTB-POZ family of transcriptional regulators and contains six Kruppel-type zinc fingers. The POZ domain in the amino terminus of Bcl6 is involved in the recruitment of corepressor proteins including NCoR, BCoR, SMRT, Mi-2/NURD and several HDACs. Bcl6 promotes proliferative expansion of B-cells in the germinal center through repression of genes regulating cell cycle and differentiation. Bcl6 also suppresses the DNA damage response, to prevent class-switch recombination being repaired. Unregulated expression of Bcl6 is involved in the development of many B-cell lymphomas.

for Bcl6 antibody (mAb) (Clone IG191E)Immunogen

This Bcl6 antibody was raised against a full-length protein corresponding to human Bcl6.

for Bcl6 antibody (mAb) (Clone IG191E)Application Notes

This Bcl6 antibody has been validated for use in Western blotting and immunohistochemistry. See references for more details.

for Bcl6 antibody (mAb) (Clone IG191E)Buffer

Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.

for Bcl6 antibody (mAb) (Clone IG191E)References

This antibody has been used in the following references:
IHC: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38; Garcia JF et al (2006) Haematologica 91: 467-474.
WB: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38.

for Bcl6 antibody (mAb) (Clone IG191E)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Bcl6 antibody (mAb) (Clone IG191E)Guarantee

This product is guaranteed for 6 months from date of arrival.