Recombinant Nucleosomes

custom designed recombinant nucleosomes

ReNucs™ are Recombinant Nucleosomes designed to contain specific histone post-translational modifications, amino acid substitutions and other modifications, delivering the most biologically relevant and powerful tools for development of novel drug targets and precision medicine. Developed in our own labs, each recombinant nucleosome is comprised of octamers of designer-modified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Active Motif currently offers the widest portfolio of pre-assembled Mononucleosome and Polynucleosome proteins available – and as the Epigenetics Experts, we continue to release newly designed ReNucs every month.

Recombinant Nucleosomes

All of our recombinant nucleosomes are available in small scale and bulk quantities. For a bulk order quote, contact us.

View our flyer, for a complete listing of Recombinant Nucleosomes,Mononucleosomes, Polynucleosomes, and related proteins.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates (click image to enlarge).

Whatever your application, ReNucs™ recombinant nucleosome proteins offer the most biologically relevant substrates when compared to histone proteins alone or synthetic peptides:

  1. Mononucleosomes and Polynucleosomes available
  2. Biotinylated nucleosomes for protein-nucleosome interaction studies and pull-down assays
  3. Post-translational modifications – designed for optimal physiological relevance
  4. Amino acid mutations – as published, these ReNucs mostly closely mimic naturally occurring nucleosomes in your own experimental design.
  5. Coming Soon – Quadra-modified ReNucs, including four post-translational modifications in each nucleosome
 
Name Expressed In Format Plain Name Cat No. Price  
Recombinant Polynucleosomes (H3.1) E. coli 20 µg Recombinant Polynucleosomes (H3.1) 31466 ¥75,000 Buy
Recombinant Polynucleosomes (H3.3) E. coli 20 µg Recombinant Polynucleosomes (H3.3) 31468 ¥75,000 Buy
1 mg Recombinant Polynucleosomes (H3.3) 31868 ¥740,000 Buy
Recombinant Mononucleosomes (H3.1) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H3.1) - biotinylated 31467 ¥75,000 Buy
Recombinant Mononucleosomes (H3.3) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H3.3) - biotinylated 31469 ¥75,000 Buy
Recombinant Polynucleosomes H3.3 (K27M) E. coli 20 µg Recombinant Polynucleosomes H3.3 (K27M) 31562 ¥75,000 Buy
Recombinant Polynucleosomes H3.3 (G34L) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34L) 31558 ¥75,000 Buy
1 mg Recombinant Polynucleosomes H3.3 (G34L) 31958 ¥740,000 Buy
Recombinant Polynucleosomes H3.3 (G34R) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34R) 31559 ¥75,000 Buy
Recombinant Polynucleosomes H3.3 (G34V) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34V) 31560 ¥75,000 Buy
Recombinant Polynucleosomes H3.3 (G34W) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34W) 31561 ¥75,000 Buy
1 mg Recombinant Polynucleosomes H3.3 (G34W) 31961 ¥740,000 Buy
Recombinant Polynucleosomes H3.3 (K36M) E. coli 20 µg Recombinant Polynucleosomes H3.3 (K36M) 31563 ¥75,000 Buy
1 mg Recombinant Polynucleosomes H3.3 (K36M) 31963 ¥740,000 Buy