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CUT&RUN (Cleavage Under Targets & Release Using Nuclease)は、様々なクロマチン関連タンパク質とその修飾のゲノムワイドな分布を調べるために用いられるエピジェネティックな手法で、ChIC (Chromatin Immunocleavage)から派生しました。CUT&RUNは、抗体を用いてクロマチン関連タンパク質を標的にするという点で、クロマチン免疫沈降法(ChIP)と類似してますが、ChIPよりも少ない細胞数と浅いシーケンス深度で実行可能です。
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