Active Motif,
Tools to analyze nuclear function,
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Histone Methylation (HMT & HDM)

epigenetic modulators of HMTs & HDMs

Histone methylation is a reversible reaction that occurs on lysine or arginine residues of histone tails. Histone methyltransferases (HMTs) catalyze the transfer of a methyl group, while histone demethylases (HDMs) perform the antagonistic action of removing the methyl group. Lysine residues can be mono-, di- or tri-methylated and arginine residues can undergo asymmetric or symmetric dimethylation. Histone methylation plays an important role in transcriptional regulation.

Active Motif offers several small molecules to study the effect of changes in HMT and HDM activity.

 
Name Appl. Format Cat No. 価格 (税抜)  
AS-8351 KDM5B Inhibitor 25 mg 14112 ¥50,000 Buy Now
5 mg 14113 ¥14,000 Buy Now
BIX-01294 G9a/GLP Inhibitor 25 mg 14072 ¥88,000 Buy Now
5 mg 14073 ¥33,000 Buy Now
Chaetocin SU(VAR)3-9 Methyltransferase Inhibitor 200 µg 14051 ¥19,000 Buy Now
Daminozide KDM2/KDM7 Inhibitor 250 mg 14058 ¥32,000 Buy Now
50 mg 14059 ¥10,000 Buy Now
DMOG PHD/JMJD2A Inhibitor 50 mg 14062 ¥54,000 Buy Now
10 mg 14063 ¥17,000 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX Inhibitor 25 mg 14068 ¥61,000 Buy Now
5 mg 14069 ¥19,000 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX Inhibitor 25 mg 14070 ¥61,000 Buy Now
5 mg 14071 ¥19,000 Buy Now
IOX1 JMJD Family Inhibitor 25 mg 14056 ¥64,000 Buy Now
5 mg 14057 ¥20,000 Buy Now
JIB-04 JMJD Family Inhibitor 25 mg 14134 ¥40,000 Buy Now
5 mg 14135 ¥14,000 Buy Now
ML-324 JMJD2 Inhibitor 25 mg 14078 ¥68,000 Buy Now
5 mg 14079 ¥21,000 Buy Now
NSC-663284 SETD8 Inhibitor 25 mg 14122 ¥68,000 Buy Now
5 mg 14123 ¥21,000 Buy Now
PBIT JARID1 Inhibitor 25 mg 14110 ¥43,000 Buy Now
5 mg 14111 ¥14,000 Buy Now
SGC707 PRMT3 Inhibitor 25 mg 14130 ¥57,000 Buy Now
5 mg 14131 ¥18,000 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 Inhibitor 250 mg 14046 ¥35,000 Buy Now
50 mg 14047 ¥11,000 Buy Now
UNC1999 EZH1 & EZH2 Inhibitor 25 mg 14114 ¥62,000 Buy Now
5 mg 14115 ¥25,000 Buy Now