Active Motif,
Tools to analyze nuclear function,
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Sirtuins (SIRT & Sir2)

epigenetic modulators of sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.

Active Motif offers several activators and inhibitors to study the effects of Sirtuins.

 
Name Appl. Format Cat No. 価格 (税抜)  
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥49,000 Buy Now
5 mg 14055 ¥16,000 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 ¥54,000 Buy Now
5 mg 14025 ¥18,000 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥62,000 Buy Now
5 mg 14029 ¥19,000 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 ¥43,000 Buy Now
5 mg 14037 ¥14,000 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 ¥43,000 Buy Now
100 mg 14023 ¥14,000 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 ¥50,000 Buy Now
5 mg 14125 ¥23,000 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 ¥123,000 Buy Now
5 mg 14081 ¥35,000 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 ¥88,000 Buy Now
5 mg 14075 ¥26,000 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥46,000 Buy Now
5 mg 14087 ¥14,000 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥64,000 Buy Now
50 mg 14117 ¥32,000 Buy Now