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Apicidin

Aliases: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
商品コード: 14040 Format: 5 mg ¥50,000 Buy Now
商品コード: 14041 Format: 1 mg ¥18,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for ApicidinChemical Properties

MW = 623.8
C34H49N5O6
CAS 183506-66-3
≥98% (HPLC); NMR (Conforms)

for ApicidinDescription

Cyclopeptide inhibitor of histone deacetylases (HDACs) (ref 1). Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces reversible transcriptional activation of p21 (WAF1) (ref 2). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines (ref 3). Cell permeable.

for ApicidinContents

White solid. May be dissolved in DMSO (10 mg/ml).

for ApicidinStorage Conditions

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

for ApicidinReferences

1. SJ Darkin-Rattray et al. Proc. Natl. Acad. Sci. USA 1996, 93:13143
2. JW Han et al. Cancer Res. 2000, 60:6068
3. SH Kim et al. Oncol. Rep. 2007, 17:647

 
Chemical structure of Apicidin.

Chemical structure of Apicidin.

 

Technical Data Sheet

Apicidin
 

Data Thumbnails

Chemical structure of Apicidin.

Chemical structure of Apicidin.
(Click image to enlarge.)