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CI-994

Aliases: N-acetyl-dinaline; 4-(Acetylamino)-N-(2-aminophenyl)benzamide; PD-123654
商品コード: 14092 Format: 25 mg ¥53,600 Buy Now
商品コード: 14093 Format: 5 mg ¥15,000 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for CI-994Chemical Properties

MW = 269.3
C15H15N3O2
CAS 112522-64-2
>98% (TLC); NMR (Conforms)

for CI-994Description

Orally active histone deacetylase (HDAC) inhibitor (IC50 = 0.9, 0.9, 1.2, and >20 µM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively) (ref1). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo (ref 2,3). Increase neuroplasticity during memory extinction (ref 4). Protects beta cells from cytokine-induced apoptosis (ref 4).

for CI-994Contents

Off-white powder. May be dissolved in DMSO (25 mg/ml).

for CI-994Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for CI-994References

1. OM Moradei et al. J. Med. Chem. 2007, 50:5543
2. T Beckers et al. Int. J. Cancer 2007, 121:1138
3. M Loprevite et al. Oncol. Res. 2005, 15:39
4. DH Chou et al. Chem. Biol. 2012, 19:669

 
Chemical structure of CI-994.

Chemical structure of CI-994.

 

Technical Data Sheet

CI-994
 

Data Thumbnails

Chemical structure of CI-994.

Chemical structure of CI-994.
(Click image to enlarge.)