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TM-2-51

Aliases: 1-Benzoyl-3-phenyl-2-thiourea
商品コード: 14096 Format: 50 mg ¥37,600 Buy Now
商品コード: 14097 Format: 10 mg ¥10,300 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for TM-2-51Chemical Properties

MW = 256.3
C14H12N2OS
CAS 4921-82-8
>98% (TLC); NMR (Conforms)

for TM-2-51Description

Highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 µM (ref1). No activation of other HDACs is observed. Rescues the activity of catalytically compromised HDAC8 mutants in vitro (ref2).

for TM-2-51Contents

Beige powder. May be dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml).

for TM-2-51Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

for TM-2-51References

1. RK Singh et al. Bioorg. Med. Chem. Lett. 2011, 21:5920
2. C Decroos et al. ACS Chem. Biol. 2014, 9:2157

 
Chemical structure of TM-2-51.

Chemical structure of TM-2-51.

 

Technical Data Sheet

TM-2-51
 

Data Thumbnails

Chemical structure of TM-2-51.

Chemical structure of TM-2-51.
(Click image to enlarge.)