ERR-α antibody (pAb)

for ERR-alpha antibody (pAb)Background

ERR-α (Estrogen-related receptor alpha, NR3B1) is an orphan nuclear receptor similar to the Estrogen Receptor. It is a sequence-specific DNA binding transcriptional activator that is constitutively active in the absence of ligand binding. No true physiological ligands have been found, but estrogen-like compounds from plants have been shown to activate ERR-α. ERR-α and ER-α have been found to regulate an overlapping set of genes, and ERR-α appears to modulate the activity of ER-α in some tissue types. ERR-α regulates genes involved in mitochondrial biogenesis, gluconeogenesis, oxidative phosphorylation, and fatty acid metabolism. ERR-α knockout mice display impaired fat metabolism and absorption.

for ERR-alpha antibody (pAb)Immunogen

This ERR-alpha antibody was raised against a peptide within the C-terminal region of human ERR alpha.

for ERR-alpha antibody (pAb)Application Notes

This ERR-α antibody has been validated for use in Western blot (1:500 - 1:1,000).

for ERR-alpha antibody (pAb)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for ERR-alpha antibody (pAb)Positive Control

Active Motif's MDA-MB-231 nuclear extract (Catalog No. 36080) can be used as a positive control for ERR-α antibody.

for ERR-alpha antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for ERR-alpha antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of arrival.