SMRT / NCoR2 antibody (mAb)

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Background

SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Immunogen

This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Application Notes

This SMRT / NCoR2 antibody has been validated for use in Western blotting. See references for details.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)References

WB: Huang EY et al (2000) Genes Dev 14: 45-54.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for SMRT / NCoR2 antibody (mAb) (Clone 5.10)Guarantee

This product is guaranteed for 6 months from date of arrival.