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Mocetinostat
| Aliases: Mocetinostat; N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide; MGCD010 |
| 商品コード: 14136 | Format: 25 mg | ¥68,000 | Buy |
| 商品コード: 14137 | Format: 5 mg | ¥20,000 | Buy |
| Application: Histone Acetylation (HAT & HDAC) |
Chemical Properties
MW = 396.4
C23H20N6O
CAS 726169-73-9
>98% (HPLC); NMR (Conforms)
Description
Class I, isoform-selective HDAC inhibitor (IC50 = 0.15, 0.29, 1.66 and 0.59 µM for HDAC1, 2, 3 and 11 respectively) (ref 1). Induces hyperacetylation of histones, induces expression of the tumor suppressor p21WAF1 and inhibits proliferation of human cancer cells (ref 2). Displays antifibrotic effects in ischemic heart failure (ref 3). Attenuates the development of hypersensitivity in models of neuropathic pain (ref 4). Active in vivo (ref 5).
Contents
Off-white crystalline powder. May be dissolved in DMSO (25 mg/ml).
References
1. N Zhou et al. J. Med. Chem. 2008, 51:4072
2. S Raeppel et al. Bioorg. Med. Chem. Lett. 2009, 19:644
3. H Nural-Govener et al. Int. J. Mol. Sci. 2015, 16:11482
4. F Denk et al. Pain 2013, 154:1668
5. C Bonfils et al. Clin. Cancer Res. 2008, 14:3441
Chemical structure of Mocetinostat.
