Chromatin Immunoprecipitation (ChIP) Resource Center

Introduction

The chromatin immunoprecipitation (ChIP) assay is the gold standard technique to analyze the binding of transcription factors and cofactors to DNA and the localization of histones and histone modifications throughout the genome.

Chromatin immunoprecipitation protocols involve a multi-step process where each step is of crucial importance to obtain interpretable and reproducible ChIP results that can be trusted. Furthermore, ChIP assays generally require a relatively high amount of starting material, which is difficult to obtain for some sample types. Although the read-out for ChIP-Seq assays has become more efficient as a result of improvements to next-generation sequencing technology in recent years, the core principles of the chromatin immunoprecipitation protocol itself have not significantly evolved since it was first developed over 30 years ago.

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