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MicroRNAs in Cancer eBook

miRNA and cancer eBook

Guide to Studying miRNAs and Performing Screens

The rapid advancements in microRNA (miRNA) research requires new experimental tools to enable scientists to accurately study the role of miRNAs in cancer and other diseases. This MicroRNAs in Cancer eBook summarizes the current miRNA research approaches and outlines how to design and execute an miRNA target screen.
This eBook covers the following topics:
  • Introduction to miRNAs and cancer
  • Experimental approaches for analyzing miRNAs
  • Performing high-throughput miRNA screens
  • Case study involving a genome-wide screen to identify new targets of miR-122

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Roles of miRNAs in Cancer Biology

MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that are important regulators of gene expression. miRNAs play a role in numerous biological processes such as cellular signaling, cell differentiation, development, and apoptosis. Mutations and improper regulation of miRNAs have been linked to a variety of physiological disorders such as cancer and heart disease. The emergence of miRNAs has been one of the defining developments in cancer biology over the past decade.