- 受託サービス
- 機能ゲノミクス - LightSwitch™
- 遺伝子発現制御
-
エピジェネティクス・クロマチン
- クロマチン再構築
- クロマチン免疫沈降 (ChIP)
- DNAメチル化解析
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ヒストン解析
- HATアッセイ(ヒストンアセチルトランスフェラーゼ)
- ヒストン脱アセチル化酵素活性(HDAC)
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Histone Modification ELISAs
- Total Histone H3 ELISA
- Histone H3 methylated Lys4 ELISA (H3K4)
- Histone H3 acetyl Lys9 ELISA (H3K9)
- Histone H3 methylated Lys9 ELISA (H3K9)
- Histone H3 acetyl Lys14 ELISA (H3K14)
- Histone H3 acetyl Lys27 ELISA (H3K27)
- Histone H3 methylated Lys27 ELISA (H3K27)
- Histone H3 phospho Ser10 ELISA (H3S10ph)
- Histone H3 phospho Ser28 ELISA (H3S28ph)
- Histone Peptide Array
- ヒストン単離
- 組換えヒストンタンパク質
- ヌクレオソーム解析
- 活性化物質 / 阻害物質
- 抗体
- 抗体標識
- リコンビナントタンパク質・酵素
- タンパク質検出・定量
- 細胞・組織・酸抽出物
- 蛍光検出・標識
- サンプル調製
- 形質転換・遺伝子発現
- バイオインフォマティクス
- Fluorescent Dyes and Antibodies
- クリックケミストリー用蛍光ツール
- MAX Stain™ Immunofluorescence Tools
- Super-Resolution Fluorescence Microscopy
- Fluorescent Kits for Cell Biology
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(871)
Antibodies
- Antibody Type
- Application
- Isotype
- Reactivity
- Modification
- Purification
- Host
- Product Category
- Histone Products
- New Products
- Sample Available
- Antibody Category
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Research Area
- (464) Chromatin & Histones
- (426) Transcription
- (179) Methylation
- (103) Acetylation & Deacetylation
- (101) Phosphorylation
- (78) Cell Cycle
- (71) DNA Damage & Repair
- (68) Cell Signaling
- (43) Apoptosis
- (21) Nuclear Receptors
- (18) Fluorescence
- (6) Oxidative Stress
- (4) Post Transcription
- (3) Immunoprecipitation
- (1) ELISAs
- (1) SUMOylation
- (1) Ubiquitination
- More
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(99)
Extracts
- Extract Type
- Extract Species
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Treatment
- (62) Untreated
- (6) TPA
- (3) IL-6
- (2) Forskolin
- (2) H2O2
- (2) Serum
- (2) TNF-α
- (2) TPA + CI
- (1) Acetaldehyde
- (1) Anacardic acid
- (1) Anisomycin
- (1) CoCl2
- (1) Colcemid
- (1) EGF
- (1) Estradiol
- (1) Etoposide
- (1) Heat shock
- (1) Hypoxia
- (1) IFNγ
- (1) IL-1α
- (1) PHA
- (1) Paclitaxel
- (1) Prolactin
- (1) Retinoic acid
- (1) Sodium butyrate
- (1) Testosterone
- More
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Cell Line / Tissue
- (18) HeLa
- (7) Hep G2
- (6) Jurkat
- (4) MCF-7
- (4) PC-12
- (3) COS-7
- (3) NIH/3T3
- (3) U-937
- (3) WI-38
- (2) A-431
- (2) C2C12
- (2) F9
- (2) K-562
- (2) LNCaP
- (2) Nb2
- (2) SL-2
- (2) T-47D
- (2) THP-1
- (1) 293
- (1) 3T3-L1
- (1) CCRM-CEM
- (1) Caco-2
- (1) DU 145
- (1) HL-60
- (1) HT-29
- (1) Human Heart
- (1) Human Liver
- (1) Human Lung
- (1) JEG-3
- (1) KG-1
- (1) LoVo
- (1) MDA-MB-231
- (1) MG-63
- (1) MIA PaCa-2
- (1) Mouse Brain
- (1) NIH:OVCAR-3
- (1) P19
- (1) PANC-1
- (1) PC-03
- (1) Raji
- (1) Rat Brain
- (1) Rat Liver
- (1) SK-N-BE
- (1) SW48
- (1) Saos-2
- (1) U-87
- (1) Y-79
- (1) ZR-75-1
- More
- Research Area
- Histone Products
- Modification
- (25) Fluorescent Dyes
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(326)
Kits
- New Products
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Product Category
- (94) Chromatin Immunoprecipitation
- (48) Phospho-protein Detection
- (44) Transcription Factor ELISAs
- (42) Sample Preparation
- (25) Epigenetic Services
- (14) DNA Methylation
- (14) Histone ELISAs
- (10) Gelshift / Supershift
- (8) Histone Assays
- (7) Antibody Labeling
- (4) Co-Immunoprecipitation
- (4) Immunofluorescence
- (3) Histone Array
- (2) Chromatin Assembly
- (2) Mitosis Assays
- (1) Nitric Oxide Assays
- (1) Nucleosomes
- (1) Protein Delivery
- (1) Ras GTPase
- (1) miRNA Target Validation
- More
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Research Area
- (176) Chromatin & Histones
- (114) Transcription
- (102) ELISAs
- (100) Immunoprecipitation
- (93) Accessories
- (78) Sample Preparation
- (77) Phosphorylation
- (60) Cell Signaling
- (48) Methylation
- (23) Cell Cycle
- (20) Apoptosis
- (16) Acetylation & Deacetylation
- (15) Sonication
- (10) DNA Damage & Repair
- (8) Fluorescence
- (3) Nuclear Receptors
- (3) Oxidative Stress
- (2) Gene Regulation
- (1) Clinical Research
- (1) DNA Methylation
- (1) Histone Post Translational Modifications
- (1) Post Transcription
- More
- Histone Products
- Modification
- Product Class
-
(610)
Recombinant Proteins
- New Products
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Protein Category
- (211) Histone
- (158) Transcription
- (57) Bromodomain
- (55) Histone Methyltransferase (HMT)
- (26) Kinase
- (24) Histone Deacetylase (HDAC)
- (20) Histone Demethylase (HDM)
- (18) DNA Damage
- (16) Nuclear Receptor
- (10) Histone Acetyltransferase (HAT)
- (9) DNA Methyltransferase (DNMT)
- (5) Cytosine Oxygenase (TET)
- (1) Glucosyltransferase
- (1) Growth Factor
- (1) Neddylation
- (1) Ubiquitination
- More
- Expressed In
- Protein Species
- Modification
-
Research Area
- (395) Chromatin & Histones
- (239) Methylation
- (201) Transcription
- (127) Acetylation & Deacetylation
- (44) Phosphorylation
- (40) Cell Signaling
- (25) Post Transcription
- (21) Cell Cycle
- (16) Nuclear Receptors
- (14) DNA Damage & Repair
- (12) Oxidative Stress
- (9) Apoptosis
- (3) Ubiquitination
- (2) Sample Preparation
- More
- Histone Products
-
(149)
Reporter Assays
- LightSwitch™ Collections
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Product Category
- (92) Synthetic Response Elements
- (11) Pathway Biomarker Sets
- (8) LightSwitch™ 3´UTR Controls
- (8) LightSwitch™ Promoter Controls
- (8) LightSwitch™ Reporter Collections
- (8) Stable Reporter Cell Lines
- (4) LightSwitch™ Empty Vectors
- (3) Gene Regulation Services
- (3) Transfection Reagents
- (2) miRNA Mimics and Inhibitors
- (1) LightSwitch™ Assay Kits
- (1) Synthetic miRNA Targets
- More
- Research Area
- miRNA Products
- Type of Control
- (59) Small Molecules
エピジェネティクス・クロマチン
Sirtuins (SIRT & Sir2)

- エピジェネティクス・クロマチン
- »
- 活性化物質 / 阻害物質
- »
- Sirtuins (SIRT & Sir2)
Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.
Active Motif offers several activators and inhibitors to study the effects of Sirtuins.
Name | Appl. | Format | Cat No. | Price | |
---|---|---|---|---|---|
AK-7 | SIRT2 Inhibitor | 25 mg | 14054 | ¥46,000 | Buy |
5 mg | 14055 | ¥14,900 | Buy | ||
BML-278 | SIRT1 Activator | 25 mg | 14024 | ¥52,000 | Buy |
5 mg | 14025 | ¥17,200 | Buy | ||
EX-527 | SIRT1 Inhibitor | 25 mg | 14028 | ¥36,800 | Buy |
5 mg | 14029 | ¥10,300 | Buy | ||
Piceatannol | SIRT1 Activator | 25 mg | 14036 | ¥40,000 | Buy |
5 mg | 14037 | ¥13,800 | Buy | ||
Resveratrol | SIRT1 Activator | 500 mg | 14022 | ¥40,000 | Buy |
100 mg | 14023 | ¥12,600 | Buy | ||
Salermide | SIRT Inhibitor | 25 mg | 14124 | ¥36,800 | Buy |
5 mg | 14125 | ¥9,200 | Buy | ||
SirtAct | SIRT1 Activator | 25 mg | 14080 | ¥69,000 | Buy |
5 mg | 14081 | ¥34,500 | Buy | ||
Sirtinol | SIRT Inhibitor | 25 mg | 14074 | ¥63,000 | Buy |
5 mg | 14075 | ¥23,000 | Buy | ||
Splitomicin | Sir2p (yeast Sirt1 homolog) Inhibitor | 25 mg | 14086 | ¥40,000 | Buy |
5 mg | 14087 | ¥11,500 | Buy | ||
Triacetyl resveratrol | SIRT Activator | 250 mg | 14116 | ¥38,000 | Buy |
50 mg | 14117 | ¥14,900 | Buy |