Sirtuins (SIRT & Sir2)

epigenetic modulators of sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.

Active Motif offers several activators and inhibitors to study the effects of Sirtuins.

 
Name Appl. Format Cat No. Price  
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥46,000 Buy
5 mg 14055 ¥14,900 Buy
BML-278 SIRT1 Activator 25 mg 14024 ¥52,000 Buy
5 mg 14025 ¥17,200 Buy
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥36,800 Buy
5 mg 14029 ¥10,300 Buy
Piceatannol SIRT1 Activator 25 mg 14036 ¥40,000 Buy
5 mg 14037 ¥13,800 Buy
Resveratrol SIRT1 Activator 500 mg 14022 ¥40,000 Buy
100 mg 14023 ¥12,600 Buy
Salermide SIRT Inhibitor 25 mg 14124 ¥36,800 Buy
5 mg 14125 ¥9,200 Buy
SirtAct SIRT1 Activator 25 mg 14080 ¥69,000 Buy
5 mg 14081 ¥34,500 Buy
Sirtinol SIRT Inhibitor 25 mg 14074 ¥63,000 Buy
5 mg 14075 ¥23,000 Buy
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥40,000 Buy
5 mg 14087 ¥11,500 Buy
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥38,000 Buy
50 mg 14117 ¥14,900 Buy