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Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.
Active Motif offers several activators and inhibitors to study the effects of Sirtuins.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| AK-7 | SIRT2 Inhibitor | 25 mg | 14054 | ¥46,000 | Buy |
| 5 mg | 14055 | ¥10,000 | Buy | ||
| BML-278 | SIRT1 Activator | 25 mg | 14024 | ¥50,000 | Buy |
| 5 mg | 14025 | ¥15,500 | Buy | ||
| EX-527 | SIRT1 Inhibitor | 25 mg | 14028 | ¥30,000 | Buy |
| 5 mg | 14029 | ¥8,800 | Buy | ||
| Piceatannol | SIRT1 Activator | 25 mg | 14036 | ¥40,000 | Buy |
| 5 mg | 14037 | ¥14,000 | Buy | ||
| Resveratrol | SIRT1 Activator | 500 mg | 14022 | ¥40,000 | Buy |
| 100 mg | 14023 | ¥13,000 | Buy | ||
| Salermide | SIRT Inhibitor | 25 mg | 14124 | ¥30,000 | Buy |
| 5 mg | 14125 | ¥8,800 | Buy | ||
| SirtAct | SIRT1 Activator | 25 mg | 14080 | ¥69,000 | Buy |
| 5 mg | 14081 | ¥30,000 | Buy | ||
| Sirtinol | SIRT Inhibitor | 25 mg | 14074 | ¥63,000 | Buy |
| 5 mg | 14075 | ¥22,000 | Buy | ||
| Splitomicin | Sir2p (yeast Sirt1 homolog) Inhibitor | 25 mg | 14086 | ¥40,000 | Buy |
| 5 mg | 14087 | ¥11,500 | Buy | ||
| Triacetyl resveratrol | SIRT Activator | 250 mg | 14116 | ¥35,000 | Buy |
| 50 mg | 14117 | ¥15,000 | Buy |
