Sirtuins (SIRT & Sir2)
epigenetic modulators of sirtuins
Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.
Active Motif offers several activators and inhibitors to study the effects of Sirtuins.
|AK-7||SIRT2 Inhibitor||25 mg||14054||¥46,000||Buy|
|BML-278||SIRT1 Activator||25 mg||14024||¥52,000||Buy|
|EX-527||SIRT1 Inhibitor||25 mg||14028||¥30,000||Buy|
|Piceatannol||SIRT1 Activator||25 mg||14036||¥40,000||Buy|
|Resveratrol||SIRT1 Activator||500 mg||14022||¥40,000||Buy|
|Salermide||SIRT Inhibitor||25 mg||14124||¥32,000||Buy|
|SirtAct||SIRT1 Activator||25 mg||14080||¥69,000||Buy|
|Sirtinol||SIRT Inhibitor||25 mg||14074||¥63,000||Buy|
|Splitomicin||Sir2p (yeast Sirt1 homolog) Inhibitor||25 mg||14086||¥40,000||Buy|
|Triacetyl resveratrol||SIRT Activator||250 mg||14116||¥38,000||Buy|