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custom designed recombinant nucleosomes

ReNucs™ are Recombinant Nucleosomes designed to contain specific histone post-translational modifications, amino acid substitutions and other modifications, delivering the most biologically relevant and powerful tools for development of novel drug targets and precision medicine. Developed in our own labs, each recombinant nucleosome is comprised of octamers of designer-modified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Active Motif currently offers the widest portfolio of pre-assembled Mononucleosome and Polynucleosome proteins available – and as the Epigenetics Experts, we continue to release newly designed ReNucs every month.

All of our recombinant nucleosomes are available in small scale and bulk quantities. For a bulk order quote, contact us

View our flyer, for a complete listing of Recombinant Nucleosomes,
Mononucleosomes, Polynucleosomes, and related proteins.

HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates (click image to enlarge).
 

Whatever your application, ReNucs™ recombinant nucleosome proteins offer the most biologically relevant substrates when compared to histone proteins alone or synthetic peptides:

  1. Mononucleosomes and Polynucleosomes available
  2. Biotinylated nucleosomes for protein-nucleosome interaction studies and pull-down assays
  3. Post-translational modifications – designed for optimal physiological relevance
  4. Amino acid mutations – as published, these ReNucs mostly closely mimic naturally occurring nucleosomes in your own experimental design.
  5. Coming Soon – Quadra-modified ReNucs, including four post-translational modifications in each nucleosome
 
Name Expressed In Format Cat No. Price  
Recombinant Histone Octamer (H3.1) E. coli 100 µg 31470 ¥74,000 Buy
1 mg 31870 ¥592,000 Buy
Recombinant Histone Octamer (H3.1) - biotinylated E. coli 50 µg 31471 ¥84,000 Buy
1 mg 31871 ¥648,000 Buy
Recombinant Histone Octamer (H3.3) E. coli 100 µg 31472 ¥74,000 Buy
1 mg 31872 ¥592,000 Buy
Recombinant Histone Octamer (H3.3) - biotinylated E. coli 50 µg 31473 ¥84,000 Buy
1 mg 31773 ¥648,000 Buy
Recombinant Mononucleosomes (H2A.Bbd) - biotinylated E. coli 20 µg 31556 ¥77,000 Buy
Recombinant Mononucleosomes (H2A.X) E. coli 20 µg 81125 ¥73,000 Buy
1 mg 81825 ¥823,000 Buy
Recombinant Mononucleosomes (H2A.X) - biotinylated E. coli 20 µg 31582 ¥77,000 Buy
Recombinant Mononucleosomes (H2A.Z) E. coli 50 µg 81072 ¥73,000 Buy
Recombinant Mononucleosomes (H2A.Z) - biotinylated E. coli 20 µg 31583 ¥77,000 Buy
Recombinant Mononucleosomes (TH2B) - biotinylated E. coli 20 µg 31557 ¥77,000 Buy