EX-527

Aliases: 6-Chloro-2,3,4,8-tetrahydro-1H-carbazole-1-carboxamide (racemic)
Catalog No: 14028 Format: 25 mg ¥36,800 Buy
Catalog No: 14029 Format: 5 mg ¥10,300 Buy
Application: Sirtuins

Chemical Properties

MW = 248.7
C13H13ClN2O
CAS 49843-98-3
>98% (TLC); NMR (Conforms)

Description

Selective SIRT1 inhibitor (IC50 = 98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage (ref 1). Causes cell cycle arrest at G1 (ref 2). Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells (ref 3). An extremely useful tool for determining the involvement of SIRT1 in cellular physiology (ref 4). Cell permeable.

Contents

Light yellow powder. May be dissolved in DMSO (18 mg/ml); Ethanol (10 mg/ml).

Storage Conditions

Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months.

References

1. JM Solomon et al. Mol. Cell Biol. 2006, 26:28
2. B Peck et al. Mol. Cancer Ther. 2010, 9:844
3. T Peled et al. Exp. Hematol.. 2012, 40:342
4. JL Andersen et al. Mol. Cell 2011, 43:834

 

Chemical structure of EX-527.