AK-7

Aliases: 3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide
Catalog No: 14054 Format: 25 mg ¥46,000 Buy
Catalog No: 14055 Format: 5 mg ¥14,900 Buy
Application: Sirtuins

Chemical Properties

MW = 437.4
C19H21BrN2O3S
CAS 420831-40-9
MP = 148-151°C
>98% (TLC); NMR (Conforms)

Description

A selective Sirt2 inhibitor (IC50 = 15.5 M) which does not bind Sirt1 or Sirt3 (ref 1). It down-regulates cholesterol biosynthesis genes in primary striatal neurons (ref 1). Displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduce brain atrophy all of which were associated with reduced aggregated mutant huntingtin (ref 2).

Contents

White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml, warm).

Storage Conditions

Store desiccated as supplied at room temperature for up to 3 years. Store solutions at -20°C for up to 3 months.

References

1. DM Taylor et al. ACS Chem. Biol. 2011, 6:540
2. V Chopra et al. Cell Rep. 2012, 2:1492

 

Chemical structure of AK-7