|Aliases: 1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid|
|Catalog No: 14058||Format: 250 mg||¥32,200||Buy|
|Catalog No: 14059||Format: 50 mg||¥10,300||Buy|
|Application: Histone Methylation (HMT & HDM)|
MW = 160.2
MP = 158-162°C >98% (TLC); NMR (Conforms)
A selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50 = 1.5, 0.55 and 2.1 µM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50 > 100 M (ref 1).
White powder. May be dissolved in DMSO (50 mg/ml); Water (20 mg/ml, warm).
Store desiccated as supplied at room temperature for up to 3 years. Store solutions at -20°C for up to 3 months.
1. NR Rose et al. J. Med. Chem. 2012, 55:6639