|Aliases: SirtAct, Sirt1 activator 3, CAY10591, 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide|
|Catalog No: 14080||Format: 25 mg||¥69,000||Buy|
|Catalog No: 14081||Format: 5 mg||¥34,500||Buy|
MW = 367.4
Physical Properties: Olive green powder >98% (TLC); NMR (Conforms)
Sirt1 activator. It suppressed TNFα release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells (ref 1). SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice (ref 2). It inhibited NFκB activation and reduced inflammatory cytokine production in lamina propria mononuclear cells from IBD patients (ref 3). It prevented and cured experimental Colitis in a mouse model (ref 3).
Olive green powder. May be dissolved in DMSO (50 mg/ml); Ethanol (20 mg/ml, warm).
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
1. VM Nayagam et al. J. Biomol. Screen. 2006, 11:959
2. SS Barbieri et al. Circulation 2012, 126:1373
3. R Caruso et al. Mucosal Immunol. 2014, May 21 Epub