RG108

Aliases: RG-108, N-Phthalyl-L-tryptophan; or (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
Catalog No: 14104 Format: 25 mg ¥40,000 Buy
Catalog No: 14105 Format: 5 mg ¥12,600 Buy
Application: DNA Methylation

Chemical Properties

MW = 334.3
C19H14N2O4
CAS 48208-26-0
MP = 104°C
>98% (TLC); NMR (Conforms)

Description

A non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM)(ref 1). Inhibits DNA methylation in human and tumor cell lines without toxicity (ref 2). Enhances the reversion of neural progenitor cells to the pluripotent state (ref 3).

Contents

Tan powder. May be dissolved in DMSO (100 mg/ml); Ethanol (100 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. B Brueckner et al. Cancer Res. 2005, 65:6305
2. C Stresemann et al. Cancer Res. 2006, 66:2794
3. I Szablowska-Gadomska et al. Acta. Neurobiol. Exp. 2012, 72:337

 

Chemical structure of RG108.