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Bromodomains in Epigenetics and Disease

Bromodomains are evolutionarily conserved protein modules that recognize and bind to acetylated lysine residues, primarily on histone tails. This binding allows bromodomain-containing proteins to function as epigenetic "readers", helping to regulate gene expression, chromatin structure, and transcriptional activation. Many of these proteins play central roles in transcriptional coactivation, chromatin remodeling, or histone acetylation, and are frequently implicated in cancer, neurological disorders, and inflammatory diseases. Notably, BET family proteins (BRD2, BRD3, BRD4, BRDT) are the most well-characterized, with BRD4 emerging as a high-value drug target in oncology. Other bromodomain proteins such as CBP/p300, SMARCA4, and PBRM1 also serve as tumor suppressors or oncogenic cofactors, making them crucial to understanding and manipulating epigenetic regulation in disease.

Protein / Family	Epigenetic Function	Disease Association	Key Publications	Key Products
ATAD2	Binds acetylated histones; oncogenic co-activator for MYC	Breast, liver, lung cancers	Biju et al., Int J Biol Macromol. 2025 Han et al., Blood. 2025	Antibodies ATAD2 antibody (pAb)
BAZ1B (WSTF)	Chromatin assembly, transcription regulation, DNA repair	Williams-Beuren syndrome	Pai et al., Dev Biol. 2024 Kim et al., Nat Commun. 2024
BRD1	Component of the MOZ/MORF HAT complex; interacts with acetylated histones; coactivates nuclear receptors; regulates gene expression during development	Schizophrenia, bipolar disorder, depression, and some cancers (e.g. breast)	Zhang et al., Cell Death Dis. 2025 Wang et al., Sci Transl Med. 2024	Proteins BRD1 (556-688) protein
BRD2 (BET)	Transcriptional regulation; binds acetylated histones	Obesity, epilepsy, B-cell lymphoma	Wang et al., Biochem J. 2009 Pathak et al., Epilepsia 2018 Zou et al., Cell Biosci. 2024	Antibodies BRD2 antibody (pAb) Proteins BRD2 protein BRD2 (71-194) protein, GST-Tag BRD2 (71-194) protein BRD2 (344-455) protein, GST-Tag BRD2 (344-455) protein
BRD3 (BET)	Chromatin binding; transcriptional regulation	NUT midline carcinoma (BRD3-NUT fusion)	Hwang et al., Diagn Cytopathol. 2023 Hashimoto et al., Cancer Sci. 2024	Antibodies BRD3 antibody (pAb) Proteins BRD3 (24-144) protein BRD3 (24-144) protein, GST-Tag BRD3 (306-416) protein BRD3 (306-416) protein, GST-Tag BRD3 (BD1+BD2) protein
BRD4 (BET)	Recognizes acetyl-H3/H4; recruits P-TEFb for transcriptional elongation	AML, NUT carcinoma, breast cancer, inflammation	Umphred-Wilson et al., Nat Commun. 2025 Fan et al., Nat Commun. 2025 Zhang et al., Cell Rep. 2024 Cameron et al., Sci Adv. 2023	Antibodies BRD4 antibody (pAb) BRD4 antibody (rAb) Proteins BRD4 protein BRD4 (44-460) protein, GST-Tag BRD4 (44-460) protein BRD4 (44-168) protein, GST-Tag BRD4 (44-168) protein BRD4 (333-460) protein, GST-Tag BRD4 (333-460) protein
BRD7	Part of PBAF; cofactor of p53; chromatin remodeling	Breast, colorectal cancer	Mondal et al., Nat Commun. 2025 Guo et al., Int J Biol Sci. 2025	Antibodies BRD7 antibody (pAb) Proteins BRD7 (129-236) protein BRD7 (129-236) protein, GST-Tag
BRD8	Part of the NuA4/TIP60 histone acetyltransferase complex; binds acetylated histones and regulates DNA repair, chromatin remodeling, and transcription	Overexpressed in colorectal and hepatocellular carcinomas; potential role in tumor progression and chromatin instability	Wu et al., Eur J Med Chem. 2024 Yamaguchi et al., Cancer Sci. 2024	Proteins BRD8 / SMAP2 antibody (pAb)
BRD9	Non-BET; part of ncBAF SWI/SNF complex	AML, multiple myeloma	Lee et al., Nuc Acids Res. 2025 Lv et al., Cell Death Dis. 2025	Antibodies BRD9 antibody (pAb) BRD9 antibody (rAb) BRD9 antibody (rAb) Proteins BRD9 (130-259) protein BRD9 (130-259) protein, GST-Tag
BRDT (BET)	Testis-specific; chromatin remodeling in spermatogenesis	Male infertility; contraceptive target	F. Pietra, Chemistry Europe 2024 Zheng et al., Sci Adv. 2025	Proteins BRDT (21-137) protein BRDT (21-137) protein, GST-Tag BRDT (257-382), GST-Tag
CBP (CREBBP)	Histone acetyltransferase; bromodomain recognizes acetyl marks	Rubinstein-Taybi syndrome, lymphomas	Chen et al., J Neuropathol Exp Neurol. 2025 Liu et al., bioRxiv 2025	Antibodies CREB1 phospho Ser133 (rAb) CBP80 antibody (rAb) Proteins CREBBP (1081-1197) protein CREBBP (1075-1873) protein Kits TransAM^® CREB
p300 (EP300)	Transcription coactivator and HAT; acetylates histones and TFs	Colorectal, bladder, and hematological cancers	Sasaki et al., Nat Commun. 2024 Xu et al., Acta Neuropathol Commun. 2024 Compton et al., Mol Cell 2023	Antibodies p300 antibody (rAb) p300 antibody (mAb) Proteins p300 protein p300 protein, catalytic domain p300 (1041-1161) protein
PBRM1	Contains 6 bromodomains; tumor suppressor in PBAF complex	Clear cell renal cell carcinoma	Lane et al., Nat Commun. 2025 Yao et al., Nat Cell Biol. 2023 Petell et al., J Biol Chem. 2023	Antibodies PBRM1 antibody (pAb) Proteins PBRM1 (613-734) protein
SMARCA1 (SNF2L1)	ISWI-family chromatin remodeler; regulates nucleosome spacing and compaction; modulates gene accessibility during differentiation	Dysregulated in glioma, prostate, and other cancers; implicated in neuronal development and X-inactivation escape	Nishimura et al., J Hum Genet. 2025 Fu et al., bioRxiv 2024	Antibodies SMARCA1 / SNF2L1 antibody (mAb) SMARCA1 / SNF2L1 antibody (rAb)
SMARCA2 (BRM)	Similar to SMARCA4; SWI/SNF remodeling	Silenced in lung and other cancers	Papavassiliou et al., Trends Cancer. 2025 Guo et al., Eur J Med Chem. 2025 Deng et al., Pathol Res Pract. 2025	Antibodies SMARCA2 / BRM antibody (mAb) Proteins SMARCA2 / BRM protein SMARCA2 / BRM (1367-1511), GST-Tag SMARCA2 / BRM (1367-1511) protein SMARCA2 (636-1131) protein
SMARCA4 (BRG1)	ATPase in SWI/SNF complex; chromatin remodeling	Lung, ovarian, pediatric brain cancers	Ye et al., Cancer Lett. 2025 Wang et al., Cancer Res. 2025 Papavassiliou et al., Trends Cancer. 2025	Antibodies SMARCA4 / BRG1 antibody (mAb) SMARCA4 antibody (mAb) Proteins SMARCA4 (658-1328) protein SMARCA4 / BRG1 (1448-1569) protein SMARCA4 / BRG1 (1448-1569), GST-Tag
SMARCAL1 / HARP	Chromatin-associated annealing helicase; stabilizes stalled replication forks; aids chromatin structure restoration after replication stress	Causative mutations in Schimke Immuno-Osseous Dysplasia (SIOD); linked to genome instability in cancer and DNA damage response defects	Oak et al., medRxiv 2025 Zhao et al., Sci Rep. 2025	Antibodies SMARCAL1 / HARP antibody (mAb)
TAF1	TFIID subunit; bromodomains recognize acetylated promoters	X-linked dystonia-parkinsonism	Chen et al., Mol Cancer Ther. 2025 Burgos et al., bioRxiv 2025	Proteins Recombinant TAF1 (1522-1656) protein

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