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Recombinant beta-Catenin protein
| Aliases: CTNNB1, catenin beta 1, armadillo, CTNNB, NEDSDV, MRD19, EVR7 |
| 商品コード: 82067 | Format: 20 µg | ¥90,000 | Buy |
| 商品コード: 82667 | Format: 1 mg | ¥788,500 | Buy |
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Expressed In: Baculovirus Protein Species: Human
Contents
A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.
Background
beta-Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.
Application Notes
This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for this product is shown.
Protein Details
Recombinant beta-Catenin protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001091679.1) with an N-terminal FLAG tag. The molecular weight of beta-Catenin is 86.79 kDa.
Recombinant beta-Catenin protein
10% SDS-PAGE Coomassie staining
MW: 86.79 kDa,
Purity: ≥ 95%
Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Guarantee
This product is guaranteed for 6 months from date of receipt. This product is for research use only and is not for use in diagnostic procedures.
