Recombinant SMAD1 protein

Aliases: JV4-1, MADH1, BSP-1, Mothers Against Decapentaplegic Homolog 1
商品コード: 82069 Format: 20 µg ¥90,000 Buy
商品コード: 82669 Format: 1 mg ¥788,500 Buy

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Expressed In: Baculovirus Protein Species: Human

Contents

A representative Technical Data Sheet (TDS) is provided here. Please refer to the lot-specific TDS you will receive with your order for the lot-specific buffer contents and protein concentration.

Background

SMAD1 is a transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD1 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product.  All available data for this product is shown. 

Protein Details

Recombinant SMAD1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005891.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.53 kDa.

 
Recombinant SMAD1 protein Coommassie gel

Recombinant SMAD1 protein
10% SDS-PAGE Comassie staining
MW: 53.53 kDa
Purity: >95%

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.